Description

  • Since 1947
  • Cardiovascular Support
  • Promotes Energy Metabolism
  • Gluten, Wheat & Dairy Free
  • Suitable for Vegetarians
  • Kosher Parve
  • Dietary Supplement

Niacin (Vitamin B3), is a water-soluble vitamin and is part of the B Complex. It is required for the metabolism of carbohydrates and protein into energy. Niacin also supports cardiovascular health, promotes increased blood flow, and supports the health of the nervous system.

Suggested Use

As a dietary supplement for adults, take one (1) tablet daily, preferably at mealtime, or as directed by a healthcare practitioner.

Other Ingredients

Dicalcium phosphate, microcrystalline cellulose, vegetable stearic acid, vegetable cellulose, vegetable magnesium stearate.

Free OF: gluten, wheat, dairy, soy, yeast, sugar, sodium, artificial flavor, sweetener, preservatives and color.

Warnings

Notice: Use of this product may cause skin flushing, burning, itching, or rash. Do not take on an empty stomach.

Not intended for use by pregnant and nursing women. If you are taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement. Keep out of reach of children. Store in a cool, dry place. Do not use if outer bottle seal is missing, torn or damaged in any way.

Is Vitamin B3  Glaucoma?

Author: Dr Jin Huang, Discipline of Biomedical Science, Sydney Medical School, The University of Sydney

Vitamin B3 could prevent glaucoma

Glaucoma is a neurodegenerative eye disease characterised by the loss of ganglion cells, causing blindness. The loss in vision tends to start from the peripheral part of the visual field, resulting in tunnel vision. In most neurodegenerative diseases, impaired mitochondrial function appears to be the cause rather than the consequence. Mitochondria are the powerhouses of cells. They produce most of the cells’ energy and play a central role in cell death (Davis and Williams, 2012). Therefore, an effective treatment for neurodegenerative diseases would be to correct mitochondrial abnormalities early.

Recently, Williams and colleagues (2017) tested the above possibility using glaucoma-prone mice (DBA/2J mice). They found that “mitochondrial abnormalities are an early driver of neuronal dysfunction, occurring before detectable degeneration”. The study also reported taking vitamin B3 orally and/or gene therapy were effective when used as a preventative measure or as an intervention for glaucoma by supporting mitochondrial health and metabolism. Clear neuroprotection was already achieved at low levels of vitamin B3 with no effect on intra-ocular pressure. Excitingly, at the highest oral dose tested, “93% of eyes did not develop glaucoma”.

How does vitamin B3 work?
Water soluble vitamin B3 or niacin also called nicotinamide or nicotinic acid is essential to all living cells. Its derivatives are protective against reactive oxygen species - substances which cause cell damage and death. One of its derivatives is nicotinamide adenine dinucleotide (NAD+) which is a key molecule in energy and redox metabolism. As we age, the level of NAD+ in the eye decreases, making the cells more vulnerable to disease-related insults. In the case of glaucoma, Williams and colleagues (2017) suggest this reduction in NAD+ and antioxidant glutathione in the eye rendered ganglion cells more vulnerable to intra-ocular pressure insults. Thus, increasing NAD+ levels by consuming its precursor vitamin B3 would be protective of ganglion cells. Indeed, oral supplement of vitamin B3 significantly protected visual function in mice - decreased optic nerve degeneration and reduced ganglion cell body loss as well as preventing retinal nerve fiber layer thinning. It was surprising to observe that vitamin B3 was potent in “decreasing metabolic disruption and prevention of glaucoma” as it “prevented the majority of age-related gene expression changes within ganglion cells” (Williams et al., 2017).

Australian researchers comment on latest glaucoma findings

In the February 2017 issue of Science, Professor Ian Trounce of the Centre of Eye Research Australia (CERA), and glaucoma specialist (and managing director of CERA), Jonathan Crowston, published a perspective on these findings. While they were very excited about the potential of these findings for the human eye, they cautioned against rushing out to buy vitamin B3 until human studies have been properly carried out. 

While the mice studies showed no toxic effects of taking high doses of nicotinamide, equivalent doses will need to be tested on humans to ensure there are no side effects. High doses of vitamin B3 (niacin) are known to cause skin rashes, and while the amide form of the vitamin doesn't appear toxic at currently recommended levels, the effect of higher doses will need further study. 

Professor Trounce said that while high doses shouldn't be taken at this stage, there was nothing to stop people from continuing to take multivitamins containing nicotinamide, or from eating a diet rich in vitamin B3.